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Krutko V.N., Dontsov
V.I. System mechanisms and models of aging. The
monograph presents in a systematic form the most significant fundamental
achievements in the field of mathematical modeling, theory and methods of
describing and analyzing the processes of aging and mortality at the level of
an individual organism and population, obtained by specialists of the Methods
of statistical analysis of indicators of aging, mortality and life expectancy
are presented in an accessible form adapted for practical use. The
book can be recommended both to scientists and specialists in the field of
mathematical biology, gerontology, sociology, demography, preventive
medicine, hygiene, sanitation, human ecology, as well as to teachers and
students studying biomedical and social disciplines. Table of contents
INTRODUCTION:
the subject, history and method of mathematical gerontology 1.1. A systematic approach – a new
methodology of modern natural science 1.2. Features and significance of
the essential modeling of aging 1.3. The essential definition of
the term aging 1.4. The basic formula for
describing aging 1.5. Biochemical and thermodynamic
models of aging 1.6. Multilevel development programs
are the basis of life 1.7. Survival of aging and ageless
populations Chapter
II. THE MAIN MECHANISMS AND ESSENTIAL MODELS OF AGING 2.1. General (essential) mechanisms
of aging 2.2. Modeling of the I general
mechanism of aging 2.3. Modeling II of the general
mechanism of aging 2.4. Modeling of the III general
mechanism of aging 2.5. Modeling of the IV general
mechanism of aging 2.6. The interrelationships of the
four main mechanisms of aging CHAPTER
III. STRUCTURAL MODELS OF REGULATION AND RESTRICTION OF CELLULAR GROWTH AND
THEIR ROLE IN THE AGING PROCESS 3.1. Modeling of the initial levels
of cell division regulation 3.2. Formation of a cellular hypercycle 3.3. Consequences of the evolution
of the cellular hypercycle 3.4. External regulation of the
cellular hypercycle and its change with age 3.5. Life expectancy of organisms 3.6. The new immunoregulatory
theory of aging 3.7. Ways to restore age-depleted
regulatory programs of cell growth and division 3.8. Practical possibilities and
approaches to radical life extension CHAPTER
IV. MATHEMATICAL MODELS AND METHODS OF ANALYSIS OF INDIVIDUAL AGING 4.1. Mathematical models of
biological age 4.2. Dynamic models of aging of the
body 4.2.1. The model of the
"organism-environment" system as the basis for modeling age-related
functional changes 4.2.2. The "shagreen skin" aging model CHAPTER
V. AGE-RELATED CHANGES IN THE SYSTEMIC PROPERTIES OF THE WHOLE ORGANISM 5.1. Bio-age and the model of
the temporal system organization of human functions 5.2. Gender differences in the system
organization of functions 5.3. Age-related changes in the
system organization of functions 5.4. Factor analysis as a
method of studying the structural organization of functions CHAPTER
VI. STATISTICAL METHODS OF AGING
ANALYSIS – POPULATION ANALYSIS 6.1. Possibilities and tasks
of statistical analysis of aging 6.2. General and special
mortality rates 6.2.1. Determination of
mortality rates 6.2.2. Methods of data
standardization 6.2.3. Survival tables 6.2.4. The use of
survival tables for the analysis of experimental data on life expectancy 6.3. Life expectancy
distribution and its statistical estimates 6.3.1. Functions
characterizing the distribution of life expectancy 6.3.2. Statistical
estimates of distributions and their use as characteristics of life
expectancy 6.3.3. Types of distributions
most often used in the analysis of life expectancy 6.4. Gompertz
and Gompertz-Makem models 6.4.1. Derivation of Gompertz and Gompertz-Makem
formulas 6.4.2. The nature of
differences in life expectancy 6.4.3. Historical
dynamics of mortality 6.4.4. Regional and
gender differences in aging 6.4.5. Using the Gompertz model in experimental studies 6.5. Statistical evaluation of
the survival function and related functions 6.5.1. The case of small
samples 6.5.2. The case of
survival tables 6.6. A systematic analysis of
trends and causes of demographic catastrophe in CHAPTER
VII. COMPUTER SYSTEMS IN THE DIAGNOSIS AND PREVENTION OF AGING 7.1. Aging of the population as
a global problem of our time. 7.2. Basic computer systems for
practitioners 7.2.1. Computer system
"Nutrition for health and longevity" 7.2.2.
Computer system "Mental performance assessment system" 7.2.3. Computer system
"Diagnostics and prevention of aging" 7.2.4. Electronic textbook
"Gerontology and geroprophylaxis"
("age") 7.2.5. Computer system
"Modeling of aging processes" 7.2.6. The program for the
assessment and correction of physical performance "Physical health" 7.2.7. Biorhythm
diagnostics program 7.2.8. Computer program
"Medicinal herbs" 7.2.9. Computer program
"Stress plus" 7.3.
Virtual devices (VP) – a set of educational and research programs 7.4. A set of popular programs literature |
