Dontsov V.I. The new immune theory of aging. ISBN:
978-3-8465-1356-9. Lambert Academic Pulishing
GmbH&Co. 2011. 114 c. (Russian)
The article considers
the systemic theory of aging, created on the basis of modern scientific
methodology – system analysis, which includes existing theories of aging as
separate mechanisms. An idea of the essence, global cause and main types of
aging, mathematical models and quantitative assessment of aging of the body is
derived. Based on theoretical consideration, models and known biological facts,
it is concluded that the regulation of cell growth is a central mechanism for
the growth, development and aging of multicellular
organisms. The regulatory centers of the brain that control growth and
development carry out effects through growth factors acting on the most
important peripheral mechanism – specific populations of lymphocytes involved
not in the immune response, but in the regulation of the growth of somatic
cells. Models of the formation of such a specific system of lymphocytes in
evolution and experimental facts of their detection are presented, their
properties, changes in aging of the body and ways to restore function for the
rejuvenation of cells, tissues and the whole organism are described.
Content
Introduction..............................................................................................3
Chapter
1. Methodological
principles of studying the phenomenon of aging..5
1.1. The history of
views on the aging process...........................................5
1.2. Methodology of
cognition – a paradigm shift................................…13
1.3. System approach:
modern methodology of scientific cognition.….…14
1.4. Process models:
phenomenological and essential modeling...............17
1.5. Aging as a
global phenomenon of Being..........................................18
Chapter
2. Theoretical
approaches to the study of the phenomenon of aging....21
2.1. The essential
definition and cause of aging................................……21
2.2. The basic
formula for describing aging.........................................…23
2.3. The main global
mechanisms of aging.........................................…26
2.4. Modeling of the
main global mechanisms of aging...........................31
2.5. The regulatory
theory of aging as the main mechanism of aging .......43
2.6. Unified systemic
theory of aging......................................................54
Chapter
3. The new immuno-regulatory theory of
aging........................................................................65
3.1.
Self–organization of cellular systems is the basis for the formation of
organisms...............................65
3.2. "Cellular hypercycle" – the basis of self-regulation and
self-regulation of multicellular organisms......67
3.3. T-lymphocytes –
regulators of somatic cell growth....……………………………….………………..72
3.4. Specialized
cellular system for regulating the growth of somatic
tissues............................................75
3.5. Properties of
lymphocytes-growth regulators of somatic tissues........................................................80
3.6. A new concept of
the emergence of
immunity...............................................................................…83
3.7. A new immuno-regulatory theory of
aging.......................................................................................85
3.8. Prospects of immuno-correction of
aging.........................................................................................89
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