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THE
PROBLEM OF RADICAL INCREASE OF LIFE duration The problem of radical increase in duration
of active creative period of human life always stirred the best human minds,
but still is not solved. It is exceptionally complete, but the critical mass
of fundamental knowledge about the main mechanisms and reasons of aging,
technical means and methods of influence on these reasons (gerontoprotectors)
at last can put the problem of creating the technologies for life span extension
on practical base. Recently the leading gerontologists of the
world more and more frequently expressed the idea that the existing volume of
fundamental knowledge about the main mechanisms of aging and reasons of its
retarding allows practically to create technologies for a considerable
increase of the human active life period; that is in line with reality. These
effects have been repeatedly demonstrated on mammals. Offered technologies
for aging prophylaxis was patented and used practically in many countries
(USA, United Kingdom, China, Russia, Romania etc.). At present the main difficulty of the problem
is in lack of the strict scientific demonstration of security and
applicability of the human aging protection means for long periods of use. There
are no reliable estimations of the expected gerontoprotective effects,
expressed in extra years of active life. There are no complex schemes for
gerontology protection, giving a justified maximum effect of the life span.
The doctor will often simply refer to his authority and experience in the
field of gerontology; and for his client it will only remains to believe him
or not. Doing so, the doctor is selecting gerontology protectors on the basis
of intuition and indirect data, or bearing up on the well-known theories of
aging. This often leads to unforeseen or even negative results. The root of the above-mentioned problem lies
in the fact, that the absolutely strict demonstration of gerontology
protection effectiveness can be achieved by comparing survival curves for
experimental and control groups of clients. The length of such experiment for
humans is a few decades (for mice and rats such experiment will last 2 - 3
years). There is direct evidence of insoluble contradiction between extreme
actuality of the problem and practical impossibility of its fast solution
within the scope of the traditional strict argument paradigm. The The gist of the offered approach lies in
creating the mostly effective scheme for clinic testing of gerontoprotectors,
in terms of time, finance and personnel. It will allow gaining the level of
argument, acceptable for official validity of effectiveness of aging
prophylaxis technologies for acceptable money and period (3 to 7 years).
Complex plans for gerontology protection will be made on the basis of that, giving
a maximum proof result to 150 percent
increase in lifespan. General principles and approaches to creating
technologies of prophylaxis of aging were worked out by the project authors,
were presented in a number of monographs and publications. The leading experts of the NGC are the
authors of the given approach. They are famous for a great experience in the
field of theoretical and experimental gerontology. The last decade had seen
them organizing 12 international and all-Russia conferences dealing with
gerontology problems. In particular, they initiated all-Russia conferences
“Medical and Biological Problems of Normal and Pathological Aging” ( They have published 27 books (in Russian),
devoted to problems of study of aging mechanisms and developing methods of
its prophylaxis, among them: “The Mathematical basis of gerontology”, “Systems
mechanisms and models of aging”, “Fundamental mechanisms of
geroprophylaxis”, “Anti-Aging Medicine: Fundamental Bases”. The
authors have published 6 “Aging Prevention” yearbooks and a series of 8 monographs “Problems
of Gerontology”. We have patented methods and means, perspective for aging
prevention. Among other things, the authors have developed and approved a
general scheme for aging prophylaxis, unique techniques for qualitative
evaluation of death rate, aging, expected lifespan and biological age
indicators. Together with a computer system for optimization of individual
gerontoprotective diets, they were presented at a number of expositions. New
theories of aging were created, “The System Theory of Aging” and
“Immuno-Regulatory Theory of Aging”. Experimental proofs of the leading role
of regulatory mechanisms of aging were received, opening practical ways for
radical increase of lifespan. Aging is a principally system process!
Consequently, getting a substantial effect of its slowing down can be done
only with the help of complex systems technologies. From 40 to 100 percent
effects of increase in lifespan of some mammals have been received. We hope
to receive 150 percent increase of lifespan for multiple systems. System
technologies of gerontology protection have inevitably complex structure,
which require non-standard approaches. Durable and costly testing compel us to make
the secondary unique and key accent on using modern mathematic methods of
experiment planning with the aim of minimizing experiment means and time,
retaining the result reliability. The principal point of the author’s
approach is manifested in setting not a traditional scientific task of
receiving new reliable knowledge, but a practical task of creating a
technology with maximum approved practical effect. This allows to plan
another scheme of approbation, with nearly 10 rate reduction of the number of
examined and the time scope of experiments and with more than a 100 rate
reduction of costs for creating technologies. |