The fundamental scientific results of NGC:


The result of many years of theoretical and experimental research by NGC specialists in the field of aging prevention and anti-aging medicine were:


"Cellular hypercycle" - the development of systemic mechanisms for the interaction of cell populations, their growth and regulation, the basis of the systemic organization of multicellular, the basis of a new theory of immunity and a new immuno-regulatory theory of aging.


"General theory of health", which fits into a single holistic scheme of representation of the General Theory of human pathology and Ecology.


The "Systemic Theory of Aging" is the result of systematization and unification of the world's leading theories of aging and the main mechanisms of aging, summarizing the achievements in this field of world-renowned scientists in the field of gerontology, valeology and general pathology: D. Harman (Theory of free radicals); L. Orgel (Catastrophe of errors); V. Frolkis (Gene Regulatory Theory aging, Aging as stress); V. Dilman (Elevation theory of aging); A. Ado and A. Speransky (General theory of pathology) and a number of others. The system theory considers the aging process holistically, structures it, determines the fundamental cause of aging – the law of increasing entropy in not fully open systems, identifies the main basic aging processes, typical syndromes and mechanisms of aging, which in turn allows us to determine the main principles, schemes, ways and means of influencing aging.

 Based on this theory, a method of systemic diagnostics of aging has been developed (hardware and software complex and computer system "Diagnostics of aging: bioage" (Certificate of registration of a computer program. Ru  No. 2007614122, 2007)), as well as the methodology of systemic geroprophylaxis and bioactivation.


 The "Immuno-regulatory theory of aging" is a new look at one of the main, and for a number of reasons, the main mechanism of aging. The theory is based on domestic scientific works registered as a discovery (A.G. Babaeva et al.). It describes the cause of the main mechanism of aging (decrease in the growth potential of cells with age) as a result of changes in the regulatory hypothalamic centers of the brain. Peripheral mechanisms of such regulation have been experimentally discovered – blood regulatory factors in young animals acting through special populations of T-lymphocytes. A patent has been obtained for a method of diagnosing such regulatory factors (Ru No. 1481689).

Based on this theory, new diagnostic methods, tools and drugs for the effects on aging are being developed. In particular, experimental effects on the system of regulation of cellular growth allowed for several days to restore the growth potential of tissue in old animals to the level of young ones (a.c. A method for restoring the cellular growth potential of tissues decreasing with age (tissue rejuvenation). The patent of Russia.  No. 2400239, 09/27/2010) as well as the possibility to reduce the biological age of a person (A method of reducing biological age (rejuvenation of the body). The patent of Russia.  No. 2404784, 27.09. 2010. 11/27/2010). All this indicates that regulatory processes may play an important role in the development of age-related changes and their effects on the regulatory system can be highly effective in curbing aging and biostimulating the functions of an aging organism.


 A number of original mathematical models of aging processes in a single living organism and in a population: "Model of functional harmony", "Model of cellular growth", "Model of dynamics of viability and risk of human death", etc. The main achievements obtained by world science in this field are summarized. A new model has been created that allows us to consider the aging processes at the individual and population levels from a single point of view on the main phenomenon of aging – a decrease in the adaptive capabilities of the body with age. A mathematical model of aging has been developed that is adequate for the entire life cycle of an organism and reflects the fundamental features of changes in viability in various phases of this cycle. A theoretical analysis of the problem of using various models of aging (mortality) to optimize gerontological experiments has been carried out. Approaches have been found to significantly reduce the testing time of aging prevention products and the amount of research required.

The created models make it possible to mathematically describe the aging processes, predict the effects of geroprotectors and put geroprophylaxis on a reliable quantitative basis. In particular, model studies of various theories of aging have shown that the most significant is the regulatory mechanism of aging and pointed to promising ways of geroprophylaxis.



New experimental data and knowledge

on the mechanisms of anti–aging effects of immunomodulators - A new immune theory of aging: the ability of T-lymphocytes to directly stimulate the growth of somatic cells of the body,

about the effects and mechanisms of action of a number of potential geroprotectors of the domestic school, little known abroad, such as: Transfer factor, Alpha-fetoprotein, Galavit; Ascorbic acid, Diasponin, Hypoxytherapy, etc.;

about age-destabilizing changes in indicators of the systemic integrity of the body – the internal structure of connections;

on the possibilities of reversing the aging processes in mammals: age-related immunodeficiency (mice) and memory (rabbits) with the help of transplants of the hypothalamus centers.

• NGC specialists were the first in Russia to conduct an in-depth scientific analysis of the dynamics and causes of changes in mortality and life expectancy of the Russian population at the end of the twentieth and in the first decade of the 21st century. The following important results were obtained: the nature of the dynamics of mortality in 1985-2000 allows us to speak about its pronounced socio-economic determinism; the hypothesis of the leading role of alcoholism in the formation of the mortality rate was refuted; the consequences of the structural restructuring of Russian society turned out to be the most severe for the age group of 40-49 years; life expectancy, the intensity of aging and mortality in men are rigidly linked to the prospects of successful work; the number of human lives of Russians "paid for the reforms of the 90s" ranges from 1.1 to 3 million people. Approaches to solving the problem of correcting the consequences of the demographic catastrophe in Russia are proposed.

Mathematical methods have been developed to assess the rate of aging in various age periods by assessing age-related changes in the intensity of human mortality. The historical stability of the human aging rate is shown with a pronounced (tenfold) decrease in the total mortality of the population. It is shown that for the first time in history, since the middle of the twentieth century, there has been a decrease in the rate of human aging, mainly in middle and old age, which, in our opinion, is associated with the success of healthcare in the field of prevention of age-related diseases. This point of view is confirmed by the Theoretical model of the aging process developed by us with the allocation of aging syndromes similar to disease syndromes, which allows us to understand and recognize the possible impact of age-related disease therapy on the actual human aging process, which opens up ways to create a new generation of geroprotection based on well-tested means of treatment and prevention of age-associated diseases.

 Age dynamics, sex differences, nonlinear effects and psychophysiological correlates of mental performance were studied.  As a result of the analysis of data from a 10-year experiment to study the dynamics of indicators of mental performance (MP) and sensorimotor coordination (SC) using the computer system "SOPR-monitoring", it was confirmed that these indicators, widely used as markers of bio-age, in addition to age, can be systematically influenced by other factors. It is shown that circadian and circannular periodic components may be present in the dynamics of MP and SC indicators. The presence of correlations between the indicators of MP and SC with cortisol levels suggests that periodic components in the dynamics of performance may be due to the influence of rhythms of hormonal regulatory systems. Taking into account the revealed nonlinearities, the characteristics of the age dynamics of MP and SC in men and women are clarified. The results obtained should be taken into account when planning experiments aimed at studying the age dynamics of mental performance.

• The analysis of the relationship between life expectancy (life expectancy) and healthy life expectancy (life expectancy) in the countries of the world. As a result of statistical analysis of WHO and UN data, it has been shown that for developing countries, where infectious diseases make a large contribution to the risk of death, the increments of OPW and OPW are almost equal. In developed countries, the resources to reduce the loss of a healthy life by reducing infectious diseases are largely exhausted. A decrease in mortality in severe forms of diseases leads to an increase in the loss of a healthy life, i.e. to the multidirectional changes of the OPCW and OPCW. This group of countries is characterized by a small but steady decrease in low, compared with less developed countries, age-related death risks in almost all age groups. At the same time, the pronounced effects of the growth of OPF are delayed in time. The results obtained show that the demographic effects of the development of medicine can vary greatly depending on the initial age structure of the population, age-related risks of death and the structure of morbidity. This should be taken into account when implementing the achievements of healthcare in highly developed countries in countries with a different medical and social situation.

• An analysis of mortality rates in developed countries in the twentieth century has been carried out. The phenomenon of a decrease in the rate of aging in the second half of the twentieth century was discovered. Possible causes of this phenomenon are discussed, which open up possibilities for controlling the rate of aging.

• The analysis of the concept of human potential and methods of its measurement is carried out. A comparative cross-country analysis of the historical dynamics and trends in the development of demographic characteristics of the human potential of Russia and the world, such as the number and structure of the population, fertility, mortality, life expectancy, education, is carried out. A new method (age-related mortality rank index) has been developed for a fine comparative analysis of the health status of the population and the results of its application to analyze the situation in Russia and a number of countries around the world are presented. The results of the analysis of the socio-economic determinants of life expectancy in the countries of the world, as well as fertility, morbidity and life expectancy in Russia are presented. Innovative ways of solving complex medical and demographic problems of Russia's human potential are considered, in particular, ways to radically increase the duration of an active, healthy, creative life of Russians, opening up prospects for Russia to become one of the world leaders in life expectancy.



Applied results of NGC:

  A new method and means of stimulating the body's antioxidant system, electrochemically activated systems (EHAS), have been created. (https://www.elibrary.ru/item.asp?id=13380312) Under the leadership of the President of the NGC, Corresponding member of the Russian Academy of Medical Sciences A.A. Podkolzin, the world's first apparatus for the synthesis of ECHAS was developed, methodological recommendations were issued and dissertations on this topic were defended.


 New geroprophylactic and bioactivating effects of the drug "Transfer factor" have been studied. The effects of biostimulation and reduction of biological age have been shown in mouse experiments and human studies. Patents were obtained on "A method for restoring the cellular growth potential of tissues decreasing with age" (Patent for invention RU 2400239 C2, 09/27/2010. Application No. 2007125212/14 dated 07/04/2007.) and "Method for reducing biological age" (Patent for invention RU 2404784 C2, 11/27/2010. Application No. 2007125208/14 dated 07/04/2007.).


Different geroprotectors differ significantly in terms of cost/effect. Very cheap and effective geroprotectors have been identified. For example, geroprotective effects have been shown in the well–known ascorbic acid and the lipid-lowering drug diasponine.


Families of computer systems (more than 20 systems) of professional (for doctors) and popular (for home and family) levels have been created, automating the processes of diagnosis and prevention of aging, as well as increasing the functional reserves of the body. Among them are professional systems: "Diagnostics of aging: bio-age" (determination of biological age and aging profile), "Prevention of aging" (assistance to a doctor in choosing geroprophylaxis technologies); "Nutrition for health and longevity" (assessment and optimization of diets); The "Mental performance assessment system" (as an important biomarker of aging – this system was used in the international space experiment "Mars-500"), etc. For mass use (for home and family), a set of programs has been prepared for the assessment and selection of nutrition, diagnosis and correction of stress, assessment and correction of physical and mental performance, individual aging diagnostic systems and a number of others.


 The Project "Intelligent digital platform for personalized quality of life management "Health Heuristics" is being developed. The project received support from the National Technology Initiative. Project objectives:

• Creation of an intelligent platform that provides personalized quality of life management based on automated collection and comprehensive analysis of multimodal data about a person, his lifestyle and the environment.

• Creating an intelligent digital environment for manufacturers and users of wellness services and products.

• Within the framework of the project, a series of computer systems and applications for smartphones are being created in order to analyze and monitor individual health. Modern methods and approaches are used in the development of systems, including Big Data work and methods of Artificial Intelligence and Neural Networks.


 A hardware and software complex SKETCH (Expert Systems for Monitoring Individual Health) has been created, designed to informatively support the main functions of a new type of Health Center. The hardware and software complex "SKETCH" includes a rheoanalyzer device and a number of software modules. AIC "SKETCH" solves a wide range of tasks of systematic screening assessment of the level of psychophysiological and somatic health, functional and adaptive reserves of the body, biological age, risks of death, nutritional quality, stress levels, etc., as well as the development on this basis of individual programs for wellness, rejuvenation, aging control, reducing the risks of death.


 A new generation of devices (virtual devices - VD) has been created for education and science, as well as websites and programs for remote self-diagnosis of health and maintenance of various types of work activity of the elderly and disabled.


 A number of methodological recommendations and manuals for doctors have been developed and approved by the Ministry of Health of the Russian Federation, in particular: "Diagnosis and treatment of chronic fatigue syndrome", "Quantitative assessment of aging, life expectancy and biological age"; "General approaches to the prevention of aging"; "Optimization of preventive, health and geroprotective diets using a computer system "Nutrition for health and longevity"" etc.


 A systematic analysis of the characteristics of mortality from the most socially significant diseases in the regions of Russia and the identification of factors reducing the intensity of mortality from these causes was carried out. The analysis showed that the growth in life expectancy of the Russian population that has emerged in recent years cannot be considered sustainable, since it is countered by an increase in both the general incidence and the incidence of certain socially significant diseases: malignant neoplasms, diabetes mellitus and hypertension.  If the total mortality in Russia in the period from 2000 to 2010 The mortality rate from diseases of the circulatory system decreased by 7.2%, then the mortality rate from diseases of the circulatory system decreased by only 5.1%, the mortality rate from neoplasms did not change, and the mortality rate from diseases of the digestive system increased by 44.4%. Analysis of correlations between socio–economic and medico-demographic parameters showed that reducing poverty and income deficit in the regions of Russia can to contribute to the reduction of morbidity and mortality from infectious diseases, including tuberculosis, viral hepatitis B and C and mainly sexually transmitted diseases. However, an increase in the average income and economic activity of the population is in a reliable direct correlation with an increase in mortality from cardiovascular and oncological diseases and diseases of the digestive system, as well as with an increase in the incidence of alcoholism, drug addiction, substance abuse, diabetes mellitus and malignant neoplasms. The results of the analysis can be used to optimize socio-demographic policy and medical support for the Russian population, as well as to monitor the effectiveness of human development management at the regional and federal levels.


 A new method of comparative mortality analysis for a group of populations has been developed, based on ranking populations by mortality rate for each of the considered age ranges and calculating the rank indices of age mortality. The advantage of this method in comparison with the analysis of life expectancy, which is a convolution of age-related death risks, or age-related mortality rates, the values of which for different age groups of the same population may differ by several orders of magnitude, is the possibility of simultaneous visual display of differences in the risk of death in all age groups.


 A comprehensive method for evaluating normal aging in an experiment in mice has been created for the purpose of a comprehensive quantitative assessment of the aging process on an experimental model and evaluation of the effect, mechanism and spectrum of action of geroprotectors; in particular, at the cell level using the method of fluorescent probes and at the level of the whole organism – using specially designed virtual devices.


 Based on the Systemic Theory of Aging , the basic mechanisms of aging are identified and the means of influencing them are systematized.



Scientific and organizational activities of the NGC

NGC specialists participated in the organization and holding of more than 20 international and All-Russian conferences on gerontology, health and restorative medicine: "Biomedical issues of normal and pathological aging" Moscow, 1994; VI International Scientific and Practical Conference "Topical issues of hygiene". February 27, 2021, St. Petersburg; International Scientific and practical Conference "Implementation of management technologies in the field of improving immunity, active longevity and a healthy lifestyle". April 15-16, 2021, Kaliningrad; All-Russian scientific and practical conference with international participation "Topical issues of prevention of infectious and non-communicable diseases: epidemiological, organizational and hygienic aspects". November 16-18, 2022, Moscow; "Aging and Longevity: systemic and interdisciplinary approaches" (Moscow, 1997); "I-th Russian Congress of Gerontologists and Geriatricians" (Samara, 1999); 7th Asia/Oceania Congress of Gerontology (Tokyo, 2003); twelve international conferences "Modern technologies of rehabilitation medicine" (Sochi, 1998-2009);  V All–Russian Forum "The health of the nation is the basis of Russia's prosperity" (Moscow, 2009), four international conferences "The elderly patient. Quality of Life" (Moscow, 2019-2022); X International Symposium "Biological Mechanisms of Aging" (Kharkov, 2012), etc.


 NGC specialists have actively participated in more than 40 international and All - Russian symposiums and conferences: "Biological mechanisms of aging" (Kharkiv, 1996), "Symposium of Human Health and non-ionizing radiation" (Ljubljana, 1996), "The First Russian Congress on Pathophysiology" (Moscow, 1996), International Symposium “Nutrition and Health: biologically active food additives" (Moscow, 1996), "World Congress of Gerontology" (Adelaide, 1997), "1st Eutopean Conference on Sustainable Island Development" (Minorka, 1997), "Gordon Research Conference on the Biology of Aging" (Ventura, 1997), "First European congress on Biogerontology" (Denmark, 1998), "17 th World Congress of Gerontology of the International Association of Gerontology" (Vancuver, 2001), "VI-th European Congress of Clinical Gerontology» (Moscow, 2002), «18th World Congress of Gerontology» (Rio de Janeiro, Brazil, 2005), «VI European Congress of the International Association of Gerontology and Geriatrics (Saint Petersburg, 2006), «7th European Congress of Biogerontology»(Palermo, 2010), «Strategies for Engineered Negligible Senescence (SENS)» (Cambridge, UK, 2007, 2011) «VI Moscow International Congress "Biotechnology: State of the Art and Prospects of Development". (Moscow, 2011), "2nd International Conference Genetics of Aging and Longevity" (Moscow, 2012), International Conference "Programmed Cell Death in Biology and Medicine" (Moscow, 2012); "Biomedical issues of normal and pathological aging" Moscow, 1994; VI International Scientific and Practical Conference "Current hygiene issues". February 27, 2021, St. Petersburg.; International scientific and practical conference "Implementation of management technologies in the field of improving immunity, active longevity and a healthy lifestyle". April 15-16, 2021, Kaliningrad; All-Russian Scientific and Practical conference with international participation "Topical issues of prevention of infectious and non-communicable diseases: epidemiological, organizational and hygienic aspects". November 16-18, 2022, Moscow; annual conferences "System Analysis in Medicine" Blagoveshchensk, 2017-2023.


 NGC specialists are editors of the yearbook "Prevention of Aging" and the monographic series "Problems of Gerontology", members of the editorial boards of scientific journals: "Bulletin of Restorative Medicine", "Proceedings of the Institute of Systems Analysis of the Russian Academy of Sciences", "International Free Access"Medical Journal", "Frontiers in Genetics of Aging", "Advances in Aging Research", "World Journal of Translational Medicine", "International Journal of Clinical Medicine".


 They participate in the activities of a number of scientific councils. For example, Prof. V.N.Krutko:

• Chairman of the section "Applied Gerontology" of the Scientific Council of the Russian Academy of Medical Sciences and the Ministry of Health of the Russian Federation on Gerontology and Geriatrics;

• Member of the section "Gerontology and Geriatrics" of the Academic Council of the Ministry of Health of the Russian Federation;

• Member of the Board of the Association of Rehabilitation Medicine Specialists;

• Member of the Problem Commission "Fundamentals of Individual and Public Health" at the Presidium of the Russian Academy of Medical Sciences;

• Member of the Scientific Council of the Interregional Public Organization (NGO) "Scientific Medical Society of Gerontologists and Geriatricians";

• Chairman of the Scientific Council of the National Gerontological Center; member of the Scientific Council of the Institute of System Analysis of the Russian Academy of Sciences; member of the Dissertation Council D002.086.02 at the Institute of System Analysis of the Russian Academy of Sciences.


 Educational activities are underway. The program of the cycle of thematic improvement for doctors "Prevention of aging as a new direction of hygienic science and practice" was developed and officially approved at I.M. Sechenov Moscow State Medical University.


 NGC specialists participated in the development of 11 programs and concepts at the federal level, including: The Concept of the State Program for the Protection and Promotion of Public Health, the Comprehensive Program for the Development of the Soviet Arctic for the future up to 2000, the Concept of Environmental Safety of Russia, the Concept of Sustainable Development of Russia, the Concept of information support and the structure of the system for evaluating the effectiveness of programs to reduce child mortality mortality in the regions of the country, the Federal program "Older Generation", the Federal target program "Active longevity".


 Thanks to all these above-mentioned works, the foundations of a new Technology for the prevention of aging were laid, including: computerized procedures for determining the rate of natural aging of both the body as a whole and its individual subsystems; assessment of risk factors; determination on this basis of the expected life expectancy of a person; selection of an individual configuration of means of restraining aging processes and assistance in the application of these means in everyday practice. The fundamental novelty of this Technology lies in focusing on the diagnosis and correction of not specific diseases, but the deep processes of wear and exhaustion of functional reserves of the body during normal life, occurring in an absolutely healthy body. The technology surpasses the available foreign analogues for solving this problem:

Ø in the general methodology (author's development of a systemic theory of aging and a complex multilevel scheme of geroprophylaxis);

Ø in the diagnostic algorithm (the ability to determine both the integral biological age and the partial ages of individual body systems and calculate life expectancy, as well as the functional reserves of the body and the risk of death);

Ø the use of a wide range of computer systems for the diagnosis and prevention of aging, in particular, a computer system for optimizing individual diets that slow down aging;

Ø in the methodology of selecting and applying the configuration of aging deterrents (an integrated technology of simultaneous exposure to the main aging processes of various levels is used);


The results of the work of the NGC aimed at the development of aging prevention as a new area of medical science and practice were reported at a meeting of the Presidium of the Russian Academy of Sciences (see Bulletin of the Russian Academy of Sciences, 2006, No. 9, pp. 790-798. https://elibrary.ru/item.asp?id=9433942 ), where they received a high rating. The project "The concept and mechanisms for the implementation of the innovative program "Active longevity of Moscow residents"" became the winner of the Moscow Open competition of social innovations "The best projects for the health of Moscow and Muscovites".


The results of fundamental scientific and applied research are reflected in 30 books, collections of works, textbooks for doctors and patents, more than 300 articles in leading scientific journals (Frontiers in genetics, Aging cell, Atlas of Science, Biogerontology, Biology Bulletin, Human Physiology, Advances in Intelligent Systems and Computing, Biophysics, Doklady Biological Sciences, Mutation Research, Longevity Report, Rejuvenation Research, Advances in Gerontology, Proceedings of the Russian Academy of Sciences, Bulletin of the Russian Academy of Sciences, Reports of the Academy of Sciences, Biophysics, Biochemistry, Human Physiology, Bulletin of Restorative Medicine, Bulletin of Experimental Biology and Medicine, etc.) and reports at Russian and international congresses. The monographic series "Problems of Gerontology" is being published - 8 books of this series have been published. The main results have been published, in particular, in books such as:

1. "Immunobiology of postnatal development"  

2. "Fundamental mechanisms of geroprophylaxis",

2. "Aging: mechanisms and ways of overcoming",

3. "Mathematical foundations of gerontology",

4. "Informatics of health and longevity",

5. "Pathophysiological mechanisms of chronic fatigue syndrome",

6. "Aging, longevity and bioactivation",

8. "Systemic mechanisms and models of aging"",

9. "Analysis of trends in mortality and life expectancy of the Russian population at the end of the twentieth century",

10. "Anti–aging medicine: fundamental foundations",

11. "Human capital: a problem and a resource for innovative development of Russia",

12. "Experimental gerontology - methods of studying aging."